Self Study: Bacterial GWAS Lecture

Overview

Teaching: 0 min
Exercises: 0 min

Questions

• Can we associate the presence of genes with phenotypes

• What is population structure correction

• How do we deal with false positives?

Objectives

• Understanding contingency testing for Genome Wide Association Studies

Bacterial Genome Wide Association Studies (GWAS)

We will follow a live lecture on GWAS. There will also be time to ask questions about the previous day or the day ahead. The lecture is available here: https://klif.uu.nl/klif/mgen/GWAS.pdf

The lecture takes 45-60 minutes depending on the questions.

Key Points

• GWAS is the association of genes, snps, kmers with phenotypes observed

• Population structure is needed to correct for linkage disequilibrium

• Multiple testing correction is needed to deal with false positives